Manchester United will have it all to do when they travel to take on PSG at the Parc Des Princes.
The Red Devils slumped to a 2-0 first leg defeat at Old Trafford and will need to pull off the ultimate comeback to reach the quarter finals.
That task will be much harder with the English side missing a lot of key players through injury.
The likes of Jesse Lingard, Nemanja matic, Ander Herrera and Anthony martial have all been ruled out, while Paul Pogba will be unavailable due to suspension.
PSG on the other hand have remained unbeaten in Ligue 1 since that tie, with Kylian Mbappe and Angel Di Maria stepping up after injury to Neymar.
Barring a collapse similar to the one they endured against Barcelona two seasons ago, Le Parisiens will certainly go through to yet another quarter final.
FC Porto will be looking to overturn a 2-1 first leg deficit when they host As Roma at the Estadio Do Dragao.
Porto did well to snatch an away goal after Nicolo Zaniolo’s brace put the Italian side in the driving sit, but they come into this game on the back of a disappointing league defeat to rivals Benfica at the weekend, which set them two points behind in the title race.
They have however won five of their nine two legged ties against Italian sides and have lost just once in five meetings against Roma.
Roma were semi finalists last season and will feel they are on course to go that far yet again.
Their away records in the competition hasn’t been the best however and it could work against them.
They are on the back of a disappointing loss themselves after being crushed 3-0 by Lazio in their serie a fixture.
They have kept just one clean sheet in their last nine away games in the competitions, so we could be in for a goal scoring fest.
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